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February 28, 2026Experimental NeurologyOpen Access

Mitochondrial dysfunction and disrupted neuronal lipid homeostasis in Parkinson’s disease: Potential mechanisms and therapeutic implications

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Authors

ZQZehao QuanThe University of QueenslandCKChun-Yuan KuThe University of QueenslandTXTian XieThe University of Queensland

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Implication

This scoping review reveals mitochondrial dysfunction and lipid dysregulation mechanisms in Parkinson's disease, suggesting new therapeutic targets.

Key Points

  • To explore mechanisms linking mitochondrial dysfunction and lipid dysregulation in Parkinson's disease and identify therapeutic targets.
  • Comprehensive literature search across PubMed, Embase, and Web of Science from 2015 to 2025
  • Screening and selection of eligible studies by independent reviewers
  • Synthesis of evidence on mitochondrial dysfunction and lipid dysregulation
  • Identified four interrelated mechanisms: ferroptosis, alpha-synuclein-lipid interactions, mitochondrial dysfunction, and impaired autophagy/mitophagy
  • Confirmed that these mechanisms lead to oxidative stress and bioenergetic collapse in dopaminergic neurons
  • Highlighted therapeutic strategies targeting iron accumulation and lipid peroxidation as promising approaches

Cite This Study

Quan et al. (2026) studied this question.

synapsesocial.com/papers/69a286c90a974eb0d3c020d8https://doi.org/10.1016/j.expneurol.2026.115703
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal2014 · 6,426 citations
  2. 2LRRK2 Attenuates Antioxidant Response in Familial Parkinson’s Disease Derived Neural Stem Cells2023 · 12 citations
  3. 3Correction: Alpha-Synuclein Is a Cellular Ferrireductase2011 · 55 citations
  4. 4On Disease Modifying and Neuroprotective Treatments for Parkinson's Disease: Physical Exercise2022 · 18 citations
  5. 5Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase1996 · 1,278 citations