Integrative Analysis of Bacterial Diversity in Patients with Type 2 Diabetes Mellitus and Periodontitis Using a Case-Control Microbiome Approach

Héctor Martínez-Gregorio; Fernando Vallejo-Lecuona; Fernando Ambriz-Barrera; Miguel Ruiz-De-La-Cruz; Julieta Aurora Morales-Valdez; Ernesto Arturo Rojas-Jiménez; Marcela Sofía Jiménez-Martínez; Eric Monroy-Pérez; Gloria Luz Paniagua-Contreras; Clara Estela Díaz-Velásquez; Felipe Vaca‐Paniagua

doi:10.1093/jambio/lxag051

February 26, 2026Journal of Applied MicrobiologyOpen Access

Integrative Analysis of Bacterial Diversity in Patients with Type 2 Diabetes Mellitus and Periodontitis Using a Case-Control Microbiome Approach

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Key Points

The research aims to investigate the relationship between bacterial diversity and type 2 diabetes mellitus (T2DM) in the context of periodontitis.
Conducted a case-control microbiome analysis.
Analyzed salivary samples from patients with T2DM and periodontitis.
Identified bacterial taxa and functional pathways.
Detected significant shifts in salivary microbial composition in T2DM patients.
Linked specific taxa to the presence of periodontitis.
Predicted functional pathways associated with altered microbial diversity.

Implication

Integrative analysis reveals microbial shifts linked to periodontitis in type 2 diabetes patients, suggesting health impacts.

Abstract

T2DM is associated with distinct shifts in salivary microbial composition and predicted function, revealing taxa and pathways linked to periodontitis.

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Cite This Study

Martínez-Gregorio et al. (2026) studied this question.

synapsesocial.com/papers/69a286da0a974eb0d3c021a4 https://doi.org/10.1093/jambio/lxag051

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Integrative Analysis of Bacterial Diversity in Patients with Type 2 Diabetes Mellitus and Periodontitis Using a Case-Control Microbiome Approach

Key Points

Implication

Abstract

Discussion

Cite This Study

Integrative Analysis of Bacterial Diversity in Patients with Type 2 Diabetes Mellitus and Periodontitis Using a Case-Control Microbiome Approach

Key Points

Implication

Abstract

Discussion

Cite This Study

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