Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity

Q: What does this research mean for the field?

The study identifies a novel evasin that inhibits both CC and CXC chemokines, demonstrating its potential as a unique therapeutic agent. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Surendra Kunwar; Shankar Raj Devkota; Caroline Ang; Pramod Aryal; Wenrui Gai; Rina Pokhrel; Sean S. So; Wanting Jiao; Richard J. Payne; Remy Robert; Martin J. Stone; Ram Prasad Bhusal

doi:10.1016/j.str.2026.02.001

February 1, 2026StructureOpen Access

Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity

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Key Points

To identify and characterize a distinct evasin that inhibits chemokines involved in immune responses.
Utilization of biochemical assays to assess chemokine activity
Comparison with existing evasins
Evolutionary analysis to understand distinctiveness
The newly discovered evasin effectively inhibits both CC and CXC chemokines
Demonstrated unique structural features compared to other evasins
Potential therapeutic applications in modulating immune responses

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Implication

This research discovers a novel evasin that inhibits both CC and CXC chemokines, suggesting new therapeutic avenues.

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Cite This Study

Kunwar et al. (2026) studied this question.

synapsesocial.com/papers/69a286eb0a974eb0d3c02372 https://doi.org/10.1016/j.str.2026.02.001

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Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity

Key Points

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Implication

Abstract

Discussion

Cite This Study

Discovery of an evolutionarily distinct evasin with dual CC and CXC chemokine inhibitory activity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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