This research examines alternative reactions to produce β-lactam and acetylglycine derivatives, indicating new synthetic routes.
It was shown that the reaction of -butyl -(diphenylmethylene)glycinate with 2-methyl-3-{[-butyl(dimethyl)silyl]oxy}propanoic acid chloride in CHCl in the presence of CsCO proceeds with the formation of the corresponding β-lactam and an acetylglycine derivative. Under the same conditions, acetyl chloride reacts with -butyl -(diphenylmethylene)glycinate chemoselectively, yielding exclusively -butyl ester of acetylglycine.
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Z.R. Valiullina (2025) studied this question.
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