Outcomes and disease activity during and after pregnancy in Asian women with MOGAD

This first international multicenter study evaluated pregnancy outcomes and their influence on disease activity in Asian women with myelin oligodendrocyte glycoprotein-antibody-associated disease (MOGAD) meeting the 2023 diagnostic criteria. Among 318 women with adult-onset MOGAD, 23 pregnancies after disease onset in 18 women were analyzed. Pregnancy outcomes were generally favorable, with most infants born healthy. Relapse rates decreased during pregnancy and returned postpartum. Three-quarters of women with previously monophasic disease transitioned to a relapsing course postpartum, although most attacks during and after pregnancy recovered well. These findings suggest that pregnancy can be considered with appropriate clinical monitoring in women with MOGAD.