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This synthesis method produces optically pure macrocyclic polylactones using natural ingredients, suggesting a green approach to chemical manufacturing.
An effective synthesis of optically pure macrocycloploylactones is proposed based on sequential reactions [1+1] - condensation of natural triol (castor oil) with sulfuric acid chloride (thionyl chloride) in carbon tetrachloride in the presence of dimethylformamide and a catalyst N,N - dimethylaminopyridine, and then the resulting macrocyclic alcohol with sebacic acid dichloride under similar conditions.
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M. P. Yakovleva (2025) studied this question.
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