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February 28, 2026Journal of Proteome Research

Enrichment and Preservation of Urine Metabolites Using Styrene Divinylbenzene Reversed Phase Sulfonate (SDB-RPS) Disks for Enhanced Biomarker Discovery and Disease Monitoring

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Authors

AWA. WangJXJiyu XuJSJian Sun

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Overview

Evaluates SDB-RPS disks for enhancing metabolite preservation in urine, indicating potential for disease monitoring.

Key Points

  • The primary aim is to evaluate SDB-RPS disks in preserving and enriching urine metabolites for improved biomarker discovery.
  • Utilized ultraperformance liquid chromatography-mass spectrometry (UPLC-MS) for analysis.
  • Conducted comparison between SDB-RPS-enriched and untreated urine over three experimental parts.
  • Examined degradation kinetics at various temperatures with constant humidity.
  • Performed disease classification using samples from hepatitis and cirrhosis.
  • Metabolite identification consistency was 88.26% between SDB-RPS and untreated urine samples.
  • AUC values for disease classification were 0.867 and 0.828 for SDB-RPS in training and validation sets, respectively.
  • SDB-RPS panels outperformed urine panels in AUC values, indicating better classification accuracy.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a287570a974eb0d3c02ec2https://doi.org/10.1021/acs.jproteome.5c00367
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