This review identifies molecular markers and lays out therapeutic approaches for stress-related CNS disorders, indicating important treatment strategies.
Key Points
This review aims to identify molecular markers associated with stress-induced central nervous system disorders and their therapeutic implications.
Analyzed 93 publications from various databases including experimental and clinical studies, reviews, and meta-analyses.
Explored epigenetic regulation, HPA axis function, and CNS remodeling in stress-exposed models.
Investigated pharmacological and non-pharmacological interventions affecting biomarkers.
Altered methylation patterns of NR3C1, FKBP5, and BDNF linked to HPA axis dysregulation.
Reduced histone acetylation and changes in microRNA profiles associated with PTSD and depression.
Partial reversibility of biomarkers noted after specific interventions, both pharmacological and non-pharmacological.