What does this research mean for the field?

A subset of patients with advanced-stage follicular lymphoma can achieve a cure with CHOP-based chemoimmunotherapy, with an overall cure rate estimated at 42%. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To examine the long-term remission and cure potential following CHOP-based regimens combined with anti-CD20 therapy in follicular lymphoma.

February 28, 2026JAMA OncologyOpen Access

Treatment of Follicular Lymphoma With CHOP and Anti-CD20 Therapy

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Authors

MSMazyar ShadmanUniversity of Washington MLMichael LeBlancFred Hutch Cancer Center LRLisa M. RimszaUniversity of Arizona

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Implication

Long-term follow-up reveals potential for cure in advanced-stage follicular lymphoma, suggesting new treatment approaches.

Key Points

To examine the long-term remission and cure potential following CHOP-based regimens combined with anti-CD20 therapy in follicular lymphoma.
Conducted a multicenter, intergroup study in the US
Patients with untreated advanced-stage follicular lymphoma enrolled from 2001 to 2008
Randomized to receive R-CHOP or CHOP-RIT and followed for 15 years
Performed cure modeling to estimate cure rates considering background mortality
15-year overall survival (OS) rate was 70%
15-year progression-free survival (PFS) was 40% overall
CHOP-RIT showed superior 15-year PFS (47% vs 34%; P = .004)
Cure modeling estimated a 42% overall cure rate
Relapse rate decreased from 6.8% in the first 5 years to 0.6% between 15 to 20 years.

Cite This Study

Shadman et al. (2026) studied this question.

synapsesocial.com/papers/69a287690a974eb0d3c030d9 https://doi.org/10.1001/jamaoncol.2026.0042

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Treatment of Follicular Lymphoma With CHOP and Anti-CD20 Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Treatment of Follicular Lymphoma With CHOP and Anti-CD20 Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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