Answers are grounded in this paper and cite their sources.
Uncovers binding pocket determinants of peptide specificity in nonribosomal peptide synthetases, suggesting pathways for design innovation.
Nonribosomal peptide synthetases (NRPSs) assemble bioactive peptides from various building blocks. The binding pocket residues governing building block specificity have allowed prediction of NRPS products but not design of specificity....
No takes yet. Share an insight, caveat, or question.
Stanišić et al. (2026) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: