Manganese-catalyzed synthesis reports efficient coupling of alcohols and naphthols, indicating broad application potential.
Benzo[f]chromane derivatives have versatile applications in organic synthesis and bioactive molecule construction. Herein, we report a manganese-catalyzed coupling of primary allylic alcohols with naphthols, establishing a route to benzo[f]chromanes via an acceptorless dehydrogenation strategy. Our protocol enabled efficient coupling of a series of primary allylic alcohols with naphthol derivatives, delivering valuable benzo[f]chromanes with high diastereoselectivity (dr up to > 20:1) in moderate to good yields (60%-86%). This methodology exhibits an extensive substrate scope (30 examples) and broad functional group compatibility.
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Ma et al. (2026) studied this question.
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