Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling

S Y Chen; Chun Wan; Chao Yu; Tianran Shen; Haoyang Zhang; Jinghe Xiao; Yiran You; Xinxin Shen; Jie Li; Wenhua Ling; Rong Huang; Hongliang Xue; Chen Xu

doi:10.1097/hep.0000000000001721

February 24, 2026Hepatology

Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling

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Key Points

The research aims to explore how dietary anthocyanins can reduce age-related hepatic steatosis through gut microbiota modulation.
Administered dietary anthocyanins, specifically Cy-3-G, to promote gut microbiota expansion.
Assessed the changes in bile acid composition post-intervention.
Evaluated activation of hepatic FXR signaling pathways.
Cy-3-G significantly expanded L. reuteri in the gut microbiota.
Bile acid composition shifted toward a more favorable profile.
Activated hepatic FXR signaling was linked to the reduction of hepatic steatosis.

Implication

Demonstrates that dietary anthocyanins alleviate hepatic steatosis in older individuals, suggesting a novel gut microbiota mechanism.

Abstract

Cy-3-G alleviates age-dependent hepatic steatosis by selectively promoting L. reuteri expansion and reshaping bile acid composition to activate hepatic FXR signaling. These findings identify a gut microbiota-mediated mechanism by which a dietary anthocyanin mitigates age-related MASLD.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a287a00a974eb0d3c03857 https://doi.org/10.1097/hep.0000000000001721

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Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

Dietary anthocyanins alleviates age-dependent hepatic steatosis by expanding Limosilactobacillus reuteri and modulating gut microbiota–bile acid–hepatic FXR signaling

Key Points

Implication

Abstract

Discussion

Cite This Study

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