pstrongAim /strongTeriparatide, a synthetic analog of the active fragment of human parathyroid hormone (PTH 1ndash;34), is a clinically approved anabolic treatment for osteoporosis. While its bone-forming capacity is well-documented, evidence regarding its systemic safety, particularly in relation to male reproductive health, remains limited./p pstrongAim:/strong This study was designed to investigate the histological consequences of prolonged teriparatide exposure on testicular architecture in adult male rats, addressing a critical gap in its toxicological profile./p pstrongMethods/strong Twenty adult male albino rats were randomly allocated into two groups. The control group received subcutaneous saline (1 mL/kg/day), while and the treated group was administered teriparatide (10 micro;g/kg/day) daily for 60 days. Testes were collected post-euthanasia, fixed in formalin, and processed for histological examination. Spermatogenic activity was assessed using Johnsenrsquo;s scoring system, and morphometric parameters, including seminiferous tubule diameter and epithelial height, were quantified. Statistical significance was determined using the Mannndash;Whitney U test (ple;0.05)./p pstrongResults /strongHistological findings revealed preserved cytoarchitecture with active spermatogenesis in control testes. The teriparatide-treated group exhibited significant degenerative changes, including epithelial detachment, interstitial edema, vascular congestion, and Leydig cell necrosis. Johnsenrsquo;s scores were significantly reduced in the treated group (median = 4.5; IQR=1.5) compared to controls (median = 8.0; IQR=2.0; plt;0.001). Furthermore, Seminiferous tubule diameter and epithelial height were markedly decreased in the treated animals./p pstrongConclusion /strongThe findings suggest that prolonged teriparatide exposure may impair permatogenesis and alter testicular structure. Re-evaluation of its reproductive safety is warranted, particularly for males of reproductive age./p
Ameen et al. (Fri,) studied this question.