What question did this study set out to answer?

To evaluate the impact of dual antiplatelet pretreatment on outcomes after intravenous thrombolysis in ischemic stroke patients.

July 1, 2018Annals of Neurology

Intravenous Thrombolysis for Ischemic Stroke Patients on Dual Antiplatelets

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Why the study?

Does intravenous thrombolysis have similar safety and efficacy in acute ischemic stroke patients on dual antiplatelet pretreatment compared to those with no antiplatelet pretreatment?

Key Points

To evaluate the impact of dual antiplatelet pretreatment on outcomes after intravenous thrombolysis in ischemic stroke patients.
Comparison of patients on dual antiplatelet therapy with those not on antiplatelets for outcomes after IV thrombolysis.
Measured outcomes include symptomatic intracerebral hemorrhage (SICH), mortality at three months, and functional status.
Patients on dual antiplatelets had similar rates of SICH compared to those not on antiplatelets.
Three-month mortality rates were equivalent between both groups.
Functional outcomes did not differ significantly, indicating no detriment from dual antiplatelet therapy.

Structured PICO

Does intravenous thrombolysis have similar safety and efficacy in acute ischemic stroke patients on dual antiplatelet pretreatment compared to those with no antiplatelet pretreatment?

Population

Acute ischemic stroke (AIS) patients eligible for intravenous thrombolysis (IVT)

Intervention

Intravenous thrombolysis (IVT) in patients with a history of dual antiplatelet pretreatment

Comparator

Intravenous thrombolysis (IVT) in patients with no antiplatelet pretreatment

Outcome

Symptomatic intracranial hemorrhage (SICH), 3-month mortality rates, and functional outcomeshard clinical

Dual antiplatelet pretreatment history should not preclude the use of intravenous thrombolysis in eligible acute ischemic stroke patients.

Implication

May support IV thrombolysis eligibility in dual antiplatelet patients; leaves open randomized confirmation.

Discussion

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Cite This Study

Tsivgoulis et al. (2018) studied this question.

synapsesocial.com/papers/69a3048a5406085704ad98c1 https://doi.org/10.1002/ana.25269

Topics

Dual antiplatelet therapy

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Intravenous Thrombolysis for Ischemic Stroke Patients on Dual Antiplatelets

Key Points

Structured PICO

Implication

Discussion

Cite This Study

Topics

Intravenous Thrombolysis for Ischemic Stroke Patients on Dual Antiplatelets

Key Points

Structured PICO

Implication

Discussion

Cite This Study

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Topics

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