What question did this study set out to answer?

The goal is to address resistance to immune checkpoint blockade in gastric cancer by identifying key regulatory factors and developing a targeted therapy.

March 1, 2026Cell Reports MedicineOpen Access

Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms

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Authors

QQQing-Zhu QiuFujian Medical University YGYou-Xin GaoFujian Medical University YZYu-Xuan ZhaoFujian Medical University

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Implication

Multi-omics analysis identifies YAP1 as a resistance factor in gastric cancer, enhancing therapy with novel nanoparticles.

Key Points

The goal is to address resistance to immune checkpoint blockade in gastric cancer by identifying key regulatory factors and developing a targeted therapy.
Conducted multi-omics profiling, including single-cell RNA sequencing and spatial transcriptomics, on gastric cancer tissues.
Identified YAP1 as a key regulator of immunosuppressive cellular communities.
Developed macrophage-membrane-camouflaged hollow mesoporous silica nanoparticles co-loaded with verteporfin and oxaliplatin.
Evaluated the efficacy of the nanoplatform in promoting immunogenic cell death and its effects on the tumor microenvironment.
YAP1 was confirmed as a significant factor contributing to immune checkpoint inhibitor non-responsiveness.
M@O-VNPs selectively inhibited YAP1, suppressing the CXCL5-CXCR2 axis.
The nanoplatform reduced the activity of SPP1+ macrophages and enhanced immune checkpoint blockade efficacy.
Combination treatment with M@O-VNPs and anti-PD-1 therapy showed synergistic antitumor effects in gastric cancer models.

Cite This Study

Qiu et al. (2026) studied this question.

synapsesocial.com/papers/69a3d6eaec16d51705d2da1f https://doi.org/10.1016/j.xcrm.2026.102635

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Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms

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Key Points

Cite This Study

Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms

Discussion

Member takes

Implication

Key Points

Cite This Study

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