The epigenomic landscape of primary tissues in osteoarthritis

We provided the largest genome-wide mQTL maps of low- and high-grade osteoarthritis cartilage and synovium. We further presented the largest cartilage eQTM map for primary cartilage and the first eQTM map in synovium. We found methylation sites with a potential mechanistically causal role in osteoarthritis and associated these with likely effector genes. Together, the presented genome-wide eQTM and mQTL maps constitute relevant resources for osteoarthritis research and beyond.