Demonstrates that limoncella apple extract preventing oxidative damage in gastrointestinal cells, suggesting potential health benefits.
Our findings show that PE increases oxidative stress, triggering epithelial-mesenchymal transition and dedifferentiation in Caco-2 cells. Interestingly, LAPE, owing to its antioxidant and anti-inflammatory properties, counteracted the harmful effects of PE, suggesting its potential as a nutraceutical strategy to prevent MP-induced damage in the gastrointestinal (GI) tract.
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Lama et al. (2026) studied this question.
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