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March 1, 20260 citationsOpen Access

Early-Onset Thiazide-Induced Hyponatremia Leading to Seizure in a Middle-Aged Woman Using Aldactazide.

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MAMehmet Zafer AydınKayseri Eğitim ve Araştırma HastanesiMTMehmet Kamil TeberZKZülfiye KuzuGeneral / Preventive / Lipids

Key Points

  • The aim is to highlight the rapid onset of thiazide-induced hyponatremia and its severe neurological consequences.
  • Descriptive case analysis of a middle-aged woman
  • Monitoring of serum sodium levels during thiazide treatment
  • Management of seizure events potentially linked to sodium imbalance
  • The patient developed hyponatremia shortly after starting thiazide therapy
  • Hyponatremia was associated with seizure activity
  • Close monitoring of serum sodium was recommended during thiazide treatment

Abstract

This case demonstrates that TIH can develop rapidly in middle-aged individuals and may lead to life-threatening neurological complications, including seizures. Clinicians should closely monitor serum sodium during the early phase of thiazide-containing diuretic therapy, particularly when combination regimens such as Aldactazide are prescribed.

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Cite This Study

Aydın et al. (2026) studied this question.

synapsesocial.com/papers/69a3d747ec16d51705d2dc85https://doi.org/10.1155/crin/9991770
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