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March 1, 2026Biomolecules & TherapeuticsOpen Access

Molecular Mechanisms Underlying the Anti-Cancer Effects of Tangeretin, a Phytochemical from Citrus Extracts

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Authors

SASeung-Hyeon AhnKCK. R. Choi

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Overview

Review highlights tangeretin's anti-cancer effects, suggesting implications for future therapies.

Key Points

  • This review aims to explore the molecular mechanisms underlying tangeretin's anti-cancer effects and its potential therapeutic applications.
  • Literature review on tangeretin's biochemical functions and mechanisms of action
  • Analysis of tangeretin's impacts on oxidative stress, tumor suppressor proteins, and cancer stem cells
  • Comparison of tangeretin with other phytochemicals and therapeutic agents
  • Tangeretin induces oxidative stress, contributing to its anti-cancer activity.
  • Tangeretin upregulates tumor suppressor proteins, aiding in cancer suppression.
  • Tangeretin reduces the proportion of cancer stem cells, which are crucial for cancer recurrence.

Cite This Study

Ahn et al. (2026) studied this question.

synapsesocial.com/papers/69a3d7baec16d51705d2dffdhttps://doi.org/10.4062/biomolther.2025.141
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tangeretin suppresses HER2-driven breast cancer via PI3K/AKT/mTOR inhibition and caspase-dependent apoptosis2026
  2. 2Phytochemicals as Promising Therapeutics in Cancer Prevention and Treatment: Mechanisms and Applications2026
  3. 3Exploring the anticancer potential of Citrus spp. essential oils against various human cancer cell lines2026
  4. 4An Update on the Potential of Tangeretin in the Management of Neuroinflammation-Mediated Neurodegenerative Disorders2024 · 14 citations
  5. 5Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic2026