Relationship Between the Ratio of Nonhigh-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol and Osteoporosis: The Mediating Role of 25(OH)D and the Moderating Effect of BMI.

Key Points

• To investigate the relationship between nonhigh-density lipoprotein and high-density lipoprotein cholesterol ratios and osteoporosis, focusing on vitamin D and BMI.
• Analyzed cholesterol ratios and their predictive ability for osteoporosis
• Evaluated the mediating effect of 25(OH)D levels
• Assessed how BMI modulates these relationships
• Nonhigh-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio predicts osteoporosis
• The impact of this ratio on bone density diminishes with higher BMI
• Vitamin D plays a crucial role in this relationship