What does this research mean for the field?

Microbial cell-free DNA sequencing can facilitate the diagnosis of culture-negative Gemella haemolysans endocarditis, guiding targeted therapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the use of plasma microbial cell-free DNA (mcfDNA) sequencing for diagnosing culture-negative Gemella haemolysans endocarditis.

March 1, 2026JACC Case Reports0 citationsOpen Access

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Microbial Cell-Free DNA Sequencing as a Novel Diagnostic for Culture-Negative Gemella haemolysans Endocarditis

TKTapendra KoiralaLouisiana State University in Shreveport PSParama SahooLouisiana State University in Shreveport SMSiddharth MahajanLouisiana State University in Shreveport

Key Points

To explore the use of plasma microbial cell-free DNA (mcfDNA) sequencing for diagnosing culture-negative Gemella haemolysans endocarditis.
Utilized plasma samples for sequencing
Analyzed microbial cell-free DNA
Assessed the ability to detect Gemella haemolysans
Identified Gemella haemolysans in culture-negative cases
Improved diagnosis accuracy using mcfDNA
Enabled more targeted therapy options for patients

Abstract

Plasma mcfDNA sequencing can facilitate diagnosis of BCNE, guiding targeted therapy.

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Cite This Study

Koirala et al. (Sun,) studied this question.

synapsesocial.com/papers/69a3d811ec16d51705d2e911 https://doi.org/https://doi.org/10.1016/j.jaccas.2026.107187

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