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March 1, 2026Investigative Ophthalmology & Visual Science0 citationsOpen Access

Ly93 Inhibits Sphingomyelin Synthesis and Attenuates Inflammation and Injury in Dry Eye Conjunctival Organoids

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QCQiankun ChenYWYuan WeiLWLeying Wang

Key Points

  • To evaluate the role of Ly93 in sphingomyelin synthesis and its effects on inflammation and injury in dry eye conditions.
  • Examined the effect of Ly93 on sphingomyelin (SM) synthesis.
  • Utilized conjunctival organoids to model dry eye disease (DED).
  • Assessed inflammation and cellular injury associated with elevated SM.
  • Inhibition of SM synthase by Ly93 led to reduced inflammation.
  • Ly93 treatment decreased cellular injury in conjunctival organoids.
  • Targeting SM metabolism showed potential as a therapeutic strategy for DED.

Abstract

Our study demonstrates that elevated SM promotes ocular surface inflammation and cellular injury. Inhibition of SM synthase by Ly93 alleviates DED-associated inflammation and injury, suggesting that targeting SM metabolism represents a promising therapeutic strategy.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69a3d811ec16d51705d2e9d1https://doi.org/10.1167/iovs.67.2.58
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