Integrating Patient Engagement into Clinical Pharmacology and Pharmacometrics: Bringing the Patient Voice into Data-Driven Science.

Patient engagement (PE) refers to the active partnership between researchers and patients throughout the research process. Here, we introduce a novel framework that embeds PE directly into quantitative modeling workflows, including model scoping and question framing, covariate selection, dose and regimen optimization, and interpretation of model outputs. Practical approaches such as feedback sessions and "data parties" demonstrate how integrating PE can systematically inform modeling decisions and ensure analyses remain patient-centered.