Mechanistic study reveals glucose metabolism dysregulation in C2C12 cells due to SARS-CoV-2 Mpro, suggesting implications for diabetes onset.
The observations suggest that the SARS-CoV-2 Mpro may be inducing an insulin-resistant state and dysregulation of glucose metabolism. Further studies are warranted to fully elucidate the mechanisms underlying the development of new-onset diabetes mellitus in patients with a history of COVID-19.
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Nhau et al. (2026) studied this question.
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