A Murine Model of HSV-1-Induced Corneal Endotheliitis: Primary Infection, Latency, and Recurrence

Yu Sun; Dingwen Cao; Jiayu Meng; Liuli Wang; Li Ma; Q J Zhou; Chao Wei; L X Xie

doi:10.1167/iovs.67.2.61

February 27, 2026Investigative Ophthalmology & Visual ScienceOpen Access

A Murine Model of HSV-1-Induced Corneal Endotheliitis: Primary Infection, Latency, and Recurrence

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Key Points

The aim is to establish a reliable murine model for studying HSV-1 induced corneal endotheliitis, including its infection phases.
Developed a murine model to simulate HSV-1 infection in corneal tissue.
Investigated phases of primary infection, latency, and recurrence in the model.
Used various assessments to analyze pathological mechanisms.
Successfully demonstrated phases of HSV-1 infection including latency and recurrence.
Provided insights into the pathological mechanisms involved in corneal endotheliitis.

Implication

Model shows HSV-1 induced corneal endotheliitis with primary infection and recurrence, suggesting a platform for treatment exploration.

Abstract

We successfully established a murine model of primary infection, latency and recurrence of HSV endotheliitis, providing a reliable platform for investigating pathological mechanisms and potential treatments.

Discussion

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Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/69a3d856ec16d51705d2f275 https://doi.org/10.1167/iovs.67.2.61

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A Murine Model of HSV-1-Induced Corneal Endotheliitis: Primary Infection, Latency, and Recurrence

Key Points

Implication

Abstract

Discussion

Cite This Study

A Murine Model of HSV-1-Induced Corneal Endotheliitis: Primary Infection, Latency, and Recurrence

Key Points

Implication

Abstract

Discussion

Cite This Study

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