Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.

Key Points

• The aim is to assess the effectiveness of IMP3 as a surrogate marker for indeterminate thyroid nodules with THADA fusion.
• Analyzed cytologic and surgical specimens for IMP3 staining.
• Evaluated the presence of THADA fusion in thyroid nodules.
• Investigated capsular and vascular invasion by correlating staining results with histopathological findings.
• IMP3 shows promising results as a surrogate marker for indeterminate thyroid nodules with THADA fusion.
• Detected subtle capsular and vascular invasion associated with IMP3 staining.