Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.

Di Ai; Youjie Zhang; Kartik Viswanathan; Jilun Zhang; Noah S. Kalman; Scott Steward-Tharp; Wen-Yu Hsiao; Qiuying Shi

doi:10.1002/cncy.70076

March 1, 2026

Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.

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Key Points

The aim is to assess the effectiveness of IMP3 as a surrogate marker for indeterminate thyroid nodules with THADA fusion.
Analyzed cytologic and surgical specimens for IMP3 staining.
Evaluated the presence of THADA fusion in thyroid nodules.
Investigated capsular and vascular invasion by correlating staining results with histopathological findings.
IMP3 shows promising results as a surrogate marker for indeterminate thyroid nodules with THADA fusion.
Detected subtle capsular and vascular invasion associated with IMP3 staining.

Implication

Demonstrates that IMP3 identifies indeterminate thyroid nodules in cytologic and surgical specimens, suggesting its clinical value.

Abstract

The current findings in a limited cohort demonstrate that IMP3 is a promising surrogate marker for indeterminate thyroid nodules with THADA fusions in both cytologic and surgical specimens. In addition, IMP3 staining may aid in detecting subtle capsular or vascular invasion.

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Cite This Study

Ai et al. (2026) studied this question.

synapsesocial.com/papers/69a3d867ec16d51705d2f2d9 https://doi.org/10.1002/cncy.70076

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Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.

Key Points

Implication

Abstract

Discussion

Cite This Study

Testing insulin-like growth factor messenger RNA-binding protein 3 as a surrogate immunohistochemical marker for indeterminate thyroid nodules with THADA fusion in both cytologic and surgical specimens.

Key Points

Implication

Abstract

Discussion

Cite This Study

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