The Relationship Between The No- Reflow Phenomenon and The Systemic Immune-Inflammation Index in Saphenous Vein Graft Interventions

Aim: In our retrospective study, we examined patients who underwent percutaneousintervention (PCI) for ischemia involving saphenous vein grafts (SVG). Ourobjective was to analyze the impact of inflammation and thrombotic events on theno-reflow phenomenon (NRP) post-intervention. For this purpose, we aimed todetermine whether the Systemic Immune-Inflammation Index (SII) is a risk factorfor the NRP. Patients were divided into two groups based on the occurrence of NRP,and we investigated whether there was a statistically significant difference in SIIbetween the groups.Materials and Methods: This retrospective study included 30 patients who hadpreviously undergone surgical revascularization and underwent PCI on SVG due toischemia between May 4, 2023, and July 31, 2024. Post-procedural blood flow wasevaluated, and patients were divided into two groups based on the development ofNRP. The relationship between NRP and SII was examined.Results: The study demonstrated that patients who experienced the NRP hadsignificantly higher SII levels. Additionally, the duration of the procedure wassignificantly longer in patients with no-reflow. Systemic risk factors, such as age,gender, and comorbidities, were similar between the no-reflow and normal flowgroups.Conclusion: This study indicates that inflammation plays a key role in determiningflow outcomes following PCI. Further clinical studies focused on reducinginflammation and improving flow are needed (PDF) The relationship between the no- reflow phenomenon and the systemic immune-inflammation index in saphenous vein graft interventions. Available from: https://www.researchgate.net/publication/384393453_The_relationship_between_the_no-_reflow_phenomenon_and_the_systemic_immune-inflammation_index_in_saphenous_vein_graft_interventions#fullTextFileContent [accessed Feb 17 2026].