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April 1, 2026

Prevalence and Risk Factors of Elevated Alanine Aminotransferase (ALT) in 2382 Treatment-naïve HBV/HDV Co-Infected Patients.

Habiba Kamal Ganbolor Jargalsaikhan Sanjaasuren Enkhtaivan Karin Lindahl Hannes Hagström Daniel Bruce Michael Ingre Bekhbold Dashtserenx Oyungerel Lkhagva-Ochir Tuvshinjargal Ulziibadrakh Andreas Bungert Heiner Wedemeyer Naranjargal B Dashdorj Soo Aleman

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Key Points

This research aims to identify the prevalence and risk factors of elevated ALT levels in treatment-naïve HBV/HDV co-infected patients.
Analyzed ALT levels in a cohort of treatment-naïve patients co-infected with HBV and HDV
Compared inflammatory processes between chronic hepatitis D and chronic hepatitis B
Evaluated the association of ALT levels with liver cirrhosis
Demonstrated that chronic hepatitis D shows an earlier and more severe inflammatory response than chronic hepatitis B
Identified significant prevalence of elevated ALT levels in the cohort
Called for longitudinal studies to enhance risk stratification for therapy prioritization

Implication

Analysis finds higher ALT levels linked to inflammatory processes in HBV/HDV co-infected individuals, suggesting targeted therapies may be needed.

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Cite This Study

Kamal et al. (2026) studied this question.

synapsesocial.com/papers/69a3d887ec16d51705d2f6bc https://doi.org/10.1111/liv.70559

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1High normal alanine aminotransferase is an indicator for better response to antiviral therapy in chronic hepatitis B2024 · 2 citations
2Early Antiviral Therapy and Hepatocellular Carcinoma Incidence in Chronic Hepatitis B Patients with Normal Alanine Aminotransferase Levels: A Prospective Phase II StudyEarly-Phase Clinical Trial · 2026
3Patients with chronic hepatitis B who have persistently normal alanine aminotransferase or aged < 30 years may exhibit significant histologic damage2024 · 12 citations
4Impact of Hepatitis B virus infection on CD4 T-cell count and ALT in HBV infected individuals: Initial insight from an underprivileged setting2024 · 1 citations
5Evaluation of Blood Donors with Elevated Serum Alanine Aminotransferase LevelsCohort Study · 1987 · 90 citations

Association of AST/ALT ratio with 90-day outcomes in patients with acute exacerbation of chronic liver disease: a prospective multicenter cohort study in China2024
Circulating metabolites are associated with persistent elevations of ALT in patients with chronic hepatitis B with complete viral suppression2024
Circulating metabolites are associated with persistent elevations of ALT in patients with chronic hepatitis B with complete viral suppression2024

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