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March 1, 2026Open Access

Selective Inhibition of Hdac6 Modulates Microglial Polarization and Attenuates Neuroinflammation in an LPS-Induced Neurodegenerative Mouse Model

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Authors

DWDr. Souravh Bais2 Mr. Ratikesh A. Wawarkar*1

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Overview

Demonstrates selective HDAC6 inhibition reduces neuroinflammation in a mouse model, suggesting a therapeutic approach for neurodegeneration.

Key Points

  • The study aims to determine how HDAC6 inhibitors affect microglial polarization and neuroinflammation in a mouse model.
  • Used lipopolysaccharide (LPS) to induce inflammation in BV-2 microglial cells.
  • Administered selective HDAC6 inhibitors like tubastatin A.
  • Analyzed changes in pro-inflammatory cytokines and M1/M2 markers using Western Blot and PCR.
  • HDAC6 inhibition significantly decreased reactive oxygen species (ROS) production.
  • Reduced expression of M1 inflammatory markers was observed.
  • Increased levels of M2-associated markers indicated a successful shift toward a neuroprotective state.

Cite This Study

Dr. Souravh Bais2 Mr. Ratikesh A. Wawarkar*1 (2026) studied this question.

synapsesocial.com/papers/69a3d89aec16d51705d2fa18https://doi.org/10.5281/zenodo.18803663
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