Longitudinal study reveals delayed sylvian fissure development linked to reduced brain oxygen levels in fetuses with congenital heart disease, suggesting a vital connection.
Delayed SF development in fetuses with CHD may be associated with the expected cerebral arterial SaO₂ reduction. Prenatal cortical folding can be reliably assessed by the SF depth/insula depth ratio or the SF depth/HC ratio.
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Xiong et al. (2026) studied this question.
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