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January 1, 1999Journal of Marine Fisheries

Myelodysplastic syndrome in an HIV-1-infected infant

H. van den Berg H. J. Scherpbier W. Kroes

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Key Points

The study aims to analyze the incidence and prognostic significance of anaplasia in Wilms tumors among HIV-1-infected infants.
Analyzed Wilms tumors from the SIOP 6 and 9 nephroblastoma trials
Classified tumors according to both original and new definitions of anaplasia
Evaluated the impact of preoperative chemotherapy on anaplasia
Anaplasia was identified in 5.5% of unilateral Wilms tumors
Overall survival rates were 75% for focal anaplasia and 41% for diffuse anaplasia
Preoperative chemotherapy did not eradicate anaplasia, confirming the new definitions as prognostically relevant.

Implication

Analysis reveals the prognostic significance of anaplastic Wilms tumor in HIV-1-infected infants, suggesting implications for treatment strategies.

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Cite This Study

Berg et al. (1999) studied this question.

synapsesocial.com/papers/69a3d8caec16d51705d2ff87 https://doi.org/10.1002/(sici)1096-911x(199905)32:5

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1New definitions of focal and diffuse anaplasia in Wilms tumor: The International Society of Paediatric Oncology (SIOP) experiencePrognostic Study · 1999 · 82 citations
2Focal Versus Diffuse Anaplasia in Wilms Tumor—New Definitions with Prognostic SignificanceCohort Study · 1996 · 230 citations
3Bilateral Wilms tumor with anaplasia: A report from the Children's Oncology Group Study AREN05342024 · 7 citations
4Data from Resolving the pathogenesis of anaplastic Wilms tumors through spatial mapping of cancer cell evolution2024
5Complete necrosis induced by preoperative chemotherapy in Wilms tumor as an indicator of low risk: Report of the International Society of Paediatric Oncology (SIOP) Nephroblastoma Trial and Study 9Prognostic Study · 2000 · 104 citations

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Complete necrosis induced by preoperative chemotherapy in Wilms tumor as an indicator of low risk: report of the international society of paediatric oncology (SIOP) nephroblastoma trial and study 92000
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