Long-Term Low-Dose of Nitrate Administration Improves Antioxidant Defence System in Insulin-Sensitive Tissues of Type 2 Diabetic Rats.

March 1, 2026Open Access

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Key Points

The research aims to investigate the effects of long-term low-dose nitrate administration on oxidative stress in insulin-sensitive tissues of type 2 diabetic rats.
Administered low-dose nitrate to rats with type 2 diabetes over a long duration.
Measured oxidative stress markers in the liver, skeletal muscle, and epicardial adipose tissue (eAT).
Compared antioxidant defense mechanisms before and after treatment.
Nitrate administration reduced markers of oxidative stress in the liver, skeletal muscle, and eAT.
Improved antioxidant defense systems were observed in insulin-sensitive tissues after long-term treatment.

Long-term nitrate treatment improves antioxidant systems in insulin-sensitive tissues, indicating potential for diabetes management.

Long-term nitrate administration at low doses has a protective effect against oxidative stress in the liver, SM and eAT of rats with T2D.

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Ghorbani et al. (2026) studied this question.

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