The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real-world data.

Key Points

• This research explores how genetic factors influence the effectiveness of statins in treating dementia.
• Emulated target trial using causal machine learning techniques
• Analyzed data integrating genetic profiles and real-world outcomes
• Focused on participants with varying polygenic risk scores (PRS)
• Participants with high non-APOE PRS showed improved cognitive outcomes with statin treatment
• Suggests that genetic susceptibility may inform treatment decisions regarding statins for dementia