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Demonstrates the association of serum GPNMB levels with aging, suggesting a potential biomarker in individuals.
Background Recently, we identified GPNMB as a marker of cellular senescence and developed a vaccine to eliminate senescent cells targeting GPNMB. However, the relationship between blood levels of this protein and individual aging has not been clarified. In the light of evidence that GPNMB is associated with individual aging both in mouse and human tissues through various omics studies, we conducted the study to test whether GPNMB level in the blood is also associated with aging and becomes a surrogate marker of aging.
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Hsiao et al. (2026) studied this question.
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