A case report uncovers baricitinib's efficacy in treating actinic granuloma after heat exposure, indicating hope for similar cases.
A 54-year-old Asian male cook had 12-month annular erythematous plaques on post-auricular regions, hand dorsa and forehead (central atrophy, mild pruritus, 0.5-8 cm), induced by prolonged heat exposure. T-spot, ANA, fungal test, and diabetes history were normal. Histopathology and reflectance confocal microscopy confirmed actinic granuloma (AG). Given AG's JAK1/2-STATs-related pathogenesis, baricitinib (2 mg/day) achieved marked improvement in 6 months, with no recurrence or adverse effects during 12-month follow-up.
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Yao et al. (2026) studied this question.
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