Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.

William Robert Kwapong; Zheli Chen; Y. Wang; Sipei Pan; Jiahui Chen; Caiyun Wen; Yinhe Liu; Ip Yiu Ming Bonaventure; Chan Chen; Zhen Wang

doi:10.1002/alz.71216

February 1, 2026

Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.

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Key Points

This research aims to explore the relationship between retinal microvascular dysfunction and cognitive decline in mild cognitive impairment (MCI).
Analyzed retinal microvascular health in individuals with mild cognitive impairment.
Assessed associations with indicators of cerebral small vessel disease and neurodegeneration.
Evaluated the role of plasma biomarkers in relation to cognitive status.
Retinal microvascular dysfunction was significantly associated with indicators of cerebral small vessel disease.
Plasma biomarkers correlated with the degree of cognitive decline observed in the participants.
Findings suggest retinal health may serve as a non-invasive biomarker for early detection of cognitive impairment.

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Implication

Observational study shows retinal dysfunction links with cognitive decline and brain health in mild cognitive impairment, suggesting potential for early diagnosis.

Abstract

Retinal microvascular dysfunction in MCI reflects concurrent cerebral SVD and neurodegeneration, supporting its potential as a non-invasive biomarker for early cognitive decline.

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Cite This Study

Kwapong et al. (2026) studied this question.

synapsesocial.com/papers/69a52de5f1e85e5c73bf1215 https://doi.org/10.1002/alz.71216

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Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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