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This research aims to investigate the role and characteristics of B cells in the tumor microenvironment of colorectal cancer.

March 2, 2026Scientific ReportsOpen Access

Immunophenotypic skewing of B cells toward IgD⁻CD27⁻IgG⁺ subtype and metabolic attenuation in colorectal cancer

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Observational study finds B cells reprogrammed in colorectal cancer, suggesting new therapeutic targets.

This research aims to investigate the role and characteristics of B cells in the tumor microenvironment of colorectal cancer.
Analyzed CRC biopsies for B cell subtypes, focusing on DN B cells.
Assessed metabolic activity and differentiation capacity of B cells.
Conducted co-culture experiments with CRC organoids to evaluate B cell functionality.
Identified increased numbers of DN B cells in CRC tissues.
Observed low metabolic activity and differentiation potential in total B cells.
Demonstrated metabolic dysfunction in B cells, with reduced glycolysis and altered mitochondrial function.

Martinis et al. (2026) studied this question.

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