Observational analysis investigates serum α-Klotho and periodontitis severity in a U.S. population, suggesting implications for biomarkers.
No significant association was found between serum α-Klotho levels and periodontitis severity. Age, smoking, and comorbidities were key predictors, highlighting the multifactorial nature of periodontitis. Further longitudinal and mechanistic studies are needed to clarify whether α-Klotho has a value as a biomarker of periodontal inflammation or disease progression.
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Sabri et al. (2026) studied this question.
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