What does this research mean for the field?

The optimal age for total knee arthroplasty to minimize the risk of adverse outcomes is below 73.5 years for 90-day mortality and readmission, and above 63.5 years for 1-year revision. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to identify the optimal age for total knee arthroplasty that reduces the risk of adverse outcomes.

March 2, 2026Open Access

Exploring the optimal age for total knee arthroplasty to minimize risk of adverse outcomes: machine learning analysis of a statewide cohort

Puntos clave

This research aims to identify the optimal age for total knee arthroplasty that reduces the risk of adverse outcomes.
Analyzed a statewide cohort using machine learning techniques.
Investigated the nonlinear relationship between age and adverse outcomes after total knee arthroplasty.
Examined specific age cutoffs for mortality, readmission, and length of stay.
Determined optimal age below 73.5 years for reducing 90-day mortality and readmission risk.
Identified age above 63.5 years as optimal for minimizing 1-year revision risk.
Confirmed significant changes in risk at specified age thresholds.

Resumen

We determined that there is a nonlinear relationship between age and risk for adverse TKA outcomes, and it changes dramatically at specific time points. Our data suggests that the optimal age for lower risk of 90-day mortality, 90-day readmission, and longer LOS is below 73.5 years, and above 63.5 years for 1-year revision. These findings can help in decision-making when trying to quantify risks related to aging.

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