A daily sotalol dose ≤400 mg or dividing doses ≥240 mg into three administrations optimizes fetal treatment efficacy and reduces maternal toxicity risk in pregnancy.
Does optimizing sotalol dosing (≤400 mg/day or divided doses ≥240 mg) balance fetal efficacy and maternal toxicity risk in fetal tachycardia?
Pregnancy PBPK modeling suggests that limiting sotalol to ≤400 mg/day or dividing doses ≥240 mg into three administrations optimizes fetal efficacy while minimizing maternal toxicity.
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Pregnancy PBPK modeling is a valuable tool for optimizing fetal sotalol therapy. A daily dose not exceeding 400 mg, or dividing daily doses of 240 mg and higher into three administrations, may optimize the balance between predicted fetal efficacy and maternal toxicity risk.
Hove et al. (Fri,) reported a other. A daily sotalol dose ≤400 mg or dividing doses ≥240 mg into three administrations optimizes fetal treatment efficacy and reduces maternal toxicity risk in pregnancy.