Void Carcinogenesis: The Multi-Hit Model as Sequential Void Activation and Immune Checkpoint Therapy as Transparency Restoration

Establishes carcinogenesis as sequential void activation at the cellular level. The multi-hit model maps to progressive escalation of void dimensions following drift cascade ordering. The 14 Hallmarks of Cancer map to void dimensions and drift stages. Immune checkpoint therapy (Nobel 2018) is formalized as transparency restoration. The irAE-response OR=23.5 empirically confirms the Fantasia Bound conjugacy cost. Carcinogens classified by void dimension. The immune system is positioned as the evolved biological void detection apparatus.