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February 6, 2026Frontiers in Bioscience-LandmarkOpen Access

LXN-THBS2 Signaling Axis Regulates Hepatic Stellate Cell Activation and Promotes the Development of Liver Fibrosis

Hao Wang Hanyu Jiang Suyi Wang Xinru Luo Xi Tan Donglin Cao Yachao Yao

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Key Points

This research explores how the LXN-THBS2 signaling axis influences hepatic stellate cell activation and liver fibrosis progression.
Investigated the role of LXN-THBS2 signaling in liver fibrosis.
Examined the activation processes of hepatic stellate cells.
Analyzed the relationship between cellular signaling and fibrosis development.
LXN-THBS2 axis significantly enhances hepatic stellate cell activation.
Activation of these cells correlates with increased liver fibrosis.
Induced activation indicates potential therapeutic targets for liver fibrosis.

Implication

Research reveals activation of hepatic stellate cells promotes liver fibrosis, highlighting a critical pathway.

Abstract

The LXN-THBS2 signaling axis may promote liver fibrosis progression by inducing the activation of HSCs.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a52f63f1e85e5c73bf23da https://doi.org/10.31083/fbl46251

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