Observational analysis reveals the role of cytokines in macrophage function, suggesting implications for inflammation management.
Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.
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Huisman et al. (2026) studied this question.
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