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March 1, 2026Journal of Cardiothoracic SurgeryOpen Access

Experience with patients presenting with the clinical features of Holt-Oram syndrome: a single center retrospective study

Xuechen Liu Lei Yang Jian Cui Mengqian Liao Zonghui Hou Mengqi Zhao Lianyi Wang

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Key Points

The study aims to analyze the cardiac and upper limb features of patients with Holt-Oram syndrome and assess surgical outcomes.
Retrospective analysis of patient data from a single center
Identification of cardiac and upper limb abnormalities
Assessment of arrhythmia types and surgical outcomes
Atrial septal defect was the most common cardiac abnormality found
Upper limb malformations included mainly polydactyly and syndactyly
Supraventricular tachycardia was the primary type of arrhythmia observed
Favorable prognosis was noted following cardiac corrective surgery

Implication

Retrospective study examines cardiac defects and arrhythmias in Holt-Oram syndrome, suggesting preventive measures.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69a67dd6f353c071a6f09e1f https://doi.org/10.1186/s13019-026-03913-4

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Holt-Oram Syndrome With Atrial Septal Defect2024
2Variation in severity of cardiac disease in Holt-Oram syndromereview · 1996 · 104 citations
3Holt-Oram Syndrome: When hand deformity leads to diagnosis of congenital heart disease2025
4When the heart and hands tell a story: an intriguing case of Holt–Oram syndrome2024 · 2 citations
5The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)other · 1994 · 396 citations

More related papers

Genetic Heterogeneity of Heart-Hand Syndromes1995
Variable Expression of the Holt-Oram Syndrome1974
ANESTHETIC MANAGEMENT OF A CHILD WITH HOLT-ORAM SYNDROME POSTED FOR DEFORMITY CORRECTION OF RADIAL CLUB HAND: A CHALLENGE2024

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