Case report shows detrimental effects on mental health and sexual function in a 46,XX male, suggesting need for multidisciplinary care.
To the best of our knowledge, this is the first case report that used validated measuring instruments to show detrimental alterations in mood, numerous facets of sexual function, and quality of life in a man with 46,XX testicular difference of sex development. Men with this syndrome should receive a multidisciplinary strategy, which includes coping with hypogonadism and psychological support, in addition to sexual dysfunction treatment. This can help patients enhance their quality of life.
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Salama et al. (2026) studied this question.
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