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This research aims to explore the protective effects of MOTS-c against liver injury induced by acetaminophen (APAP) and the underlying mechanisms involved.

March 3, 2026Protein and Peptide Letters0 citations

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MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway

NLN. Li YXYan Xu QCQ. CHEN

Key Points

This research aims to explore the protective effects of MOTS-c against liver injury induced by acetaminophen (APAP) and the underlying mechanisms involved.
Administered MOTS-c to mice exposed to acetaminophen
Evaluated liver injury markers such as oxidative stress and inflammation
Analyzed the MAPK signaling pathway components including ERK, JNK, and p38
MOTS-c administration significantly reduced liver injury in mice
The study found lower levels of oxidative stress and inflammation in treated mice
MAPK signaling pathway suppression was confirmed, correlating with reduced cell death

Abstract

This study demonstrates that administering MOTS-c effectively protects against APAP-induced liver injury in mice. The protective mechanism involves suppressing the damaging MAPK signaling pathway (ERK, JNK, p38), which in turn reduces oxidative stress, inflammation, and cell death.

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MOTS-c Protects Against Acetaminophen-induced Liver Injury through the MAPK Signaling Pathway

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