Dose-dependent effects of esketamine on the prevention of propofol-induced injection pain: a randomized controlled trial

Key Points

• Esketamine significantly reduces injection pain during propofol administration, demonstrating effective analgesic effects.
• Pain scores were notably lower in groups receiving esketamine at various doses compared to placebo with p-values indicating statistical significance.
• A randomized controlled trial examined the effects of multiple doses of esketamine on propofol-induced injection pain in a clinical setting.
• Findings support the potential for esketamine to enhance patient comfort during anesthetic procedures and warrant further research.