In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus

Wallyson André dos Santos Bezerra; Claudia Quintino da Rocha; Itabajara da Silva Vaz Junior; Shafi Ullah; Walter Filgueira de Azevedo Junior; Alexandra Martins dos Santos Soares

doi:10.1016/j.molbiopara.2026.111735

January 27, 2026Molecular and Biochemical Parasitology

In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus

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Key Points

Inhibitory effects on glutathione S-transferase were assessed using plant compounds, targeting Rhipicephalus microplus and R. decoloratus ticks.
Key results indicated that certain plant compounds reduce enzyme activity, which is crucial for tick survival and reproduction.
In vitro and in silico methods were employed to determine the efficacy of various compounds on enzyme inhibition, enhancing pest management strategies.
Findings support the development of natural agents against these tick species, promoting environmentally friendly pest control alternatives.

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Implication

In vitro and in silico analysis evaluates plant compounds to inhibit glutathione S-transferase in specific tick species, suggesting potential pest control approaches.

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Bezerra et al. (2026) studied this question.

synapsesocial.com/papers/69a75a6fc6e9836116a203f2 https://doi.org/10.1016/j.molbiopara.2026.111735

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In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus

Key Points

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Implication

Discussion

Cite This Study

In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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