FAP expression as a marker of malignant transformation enabling in vivo characterization in peripheral nerve sheath tumors: a multimodal and translational study

Nic G. Reitsam; Alexander Gäble; Lisa Siebenhüter; Tina Schaller; Friederike Liesche-Starnecker; Eva Sipos; Sebastian Dintner; Christoph Walz; John Babic; Martin Trepel; Malte Kircher; Victoria E. Fincke; Pascal D. Johann; Bruno Märkl; Constantin Lapa; Johanna S. Enke

doi:10.1007/s00401-026-02979-7

January 27, 2026Acta NeuropathologicaOpen Access

FAP expression as a marker of malignant transformation enabling in vivo characterization in peripheral nerve sheath tumors: a multimodal and translational study

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Key Points

FAP expression indicates malignant transformation in peripheral nerve sheath tumors, impacting diagnosis.
Key evidence shows enhanced tumor characterization through multimodal imaging techniques.
The study utilizes a translational approach to link FAP expression with in vivo tumor behavior.
These findings highlight FAP as a promising biomarker for assessing tumor malignancy in clinical settings.

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Implication

Observational analysis reveals FAP expression correlates with malignant transformation in peripheral nerve sheath tumors, suggesting its potential as a biomarker.

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Cite This Study

Reitsam et al. (2026) studied this question.

synapsesocial.com/papers/69a75a87c6e9836116a20733 https://doi.org/10.1007/s00401-026-02979-7

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FAP expression as a marker of malignant transformation enabling in vivo characterization in peripheral nerve sheath tumors: a multimodal and translational study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

FAP expression as a marker of malignant transformation enabling in vivo characterization in peripheral nerve sheath tumors: a multimodal and translational study

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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