Case report reveals a unique collision tumor of squamous cell carcinoma and adenocarcinoma in the prostate, suggesting new insights for diagnosis and treatment.
Primary squamous cell carcinoma (PSCC) of the prostate is a rare, aggressive malignancy that presents diagnostic and therapeutic challenges. We present a unique case of PSCC arising from squamous metaplasia coexisting with a separate adenocarcinoma, forming a collision tumor. Dual-tracer imaging demonstrated distinct FDG and PSMA-avid metastases, reflecting independent biology. This case represents, to our knowledge, the first report of a true prostatic collision tumor with independent PSCC and adenocarcinoma, expanding the spectrum of prostate cancer variants.
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Dagovetz et al. (2026) studied this question.
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